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Helga (H) Einarsdottir

Department: Experimental Immunohematology

E-mail: h.einarsdottir@sanquin.nl

Training: Biochemistry, Biomedical science, Immunology

Research interests:
FcRn (the neonatal receptor) binds IgG and is expressed in many tissues including vascular endothelium, mucosal surfaces, myeloid cells, and in the placenta. The FcRn is crucial to placental transport of antibodies to the fetus, as well as IgG homeostasis and has recently been shown to be involved in antigen presentation and phagocytosis. By changing amino acids at the FcRn binding site of IgG, one can influence the FcRn binding of the antibodies, thereby achieving the desired combination of lifetime and effector function for many medical applications. By using FcRn transfected cell lines and different subclasses and mutants of IgG, we can study the nuances of FcRn-IgG binding. By including an anti-hapten variable region in these antibodies, we can study the effect of FcRn binding on the efficiency of DC presentation of haptenized antigens, as well as the skewing and polarization of the T cell response.

Technology:
Elisa, transcytosis assays, Western blots, PCR, Taqman, transfection and production of IgG’s, cloning

Resume:
2002-2005:Bachelor's degree in Biochemistry, Chemistry department, University of Iceland, Reykjavik.
2006-2008:Master's degree in Biomedical science, Medical faculty, University of Iceland, Reykjavik.
2008-present:PhD-student, Department of Experimental Immunohematology, Sanquin Research, Amsterdam

Sanquin publications

Other publications:
Ogmundsdóttir HM, Einarsdóttir HK, Steingrímsdóttir H, Haraldsdóttir V. Familial predisposition to monoclonal gammopathy of unknown significance, Waldenström's macroglobulinemia, and multiple myeloma. Clin Lymphoma Myeloma. 2009; 9(1):27-9.



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