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Suzanne (S) van Helden PhD

Department: Molecular Cell Biology

E-mail: s.vanhelden@sanquin.nl

Training: Cell biology and immunology

Thesis:
Function and regulation of podosomes, important adhesion structures in dendritic cells
25 November 2008
Dept. Tumor Immunology (prof. dr. C. Figdor), NCMLS, Radboud University Nijmegen Medical Centre

Research interests:
Research interests are cell-matrix adhesion structures, such as focal adhesions and podosomes. Especially, the dynamic behaviour and regulation by Rho GTPases of these structures.

Technology:
Confocal microscopy, Protein Biochemistry, Flow cytometry

Resume:
2002:MSc Biology, Radboud University Nijmegen
2002-2008:PhD student, department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen MC
June 2008-present:Post-doc at the Molecular Cell Biology department, Sanquin Research, Amsterdam.

Sanquin publications

Other publications:
  • van Lieshout AW, van der Voort R, Toonen LW, van Helden SF, Figdor CG, van Riel PL, Radstake TR, Adema GJ. Regulation of CXCL16 expression and secretion by myeloid cells is not altered in rheumatoid arthritis. Ann Rheum Dis 2008 Jul 15. [Epub ahead of print].


  • van Helden SF, Oud MM, Joosten B, Peterse N, Figdor CG, van Leeuwen FN. PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis. J Cell Sci 2008; 121(Pt 7):1096-106.

  • van Helden SF, Krooshoop DJ, Broers KC, Raymakers RA, Figdor CG, van Leeuwen FN. A critical role for prostaglandin E2 in podosome dissolution and induction of high-speed migration during dendritic cell maturation. J Immunol 2006; 177(3):1567-74.

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